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Nitrous oxide and benzodiazepine cross-tolerance?

Posted by Fred23 on November 8, 2009, at 17:56:16

Would periodic recreational use of nitrous oxide use possibly increase the needed dosage I'm taking of Klonopin for its anxiolytic effect?

The Wikipedia ( has this paragraph in the Neuropharmacology section:

Unlike most general anesthetics, N2O appears to affect the GABA receptor. In many behavioral tests of anxiety, a low dose of N2O is a successful anxiolytic. This anti-anxiety effect is partially reversed by benzodiazepine receptor antagonists. Mirroring this, animals which have developed tolerance to the anxiolytic effects of benzodiazepines are partially tolerant to nitrous oxide.[13] Indeed, in humans given 30% N2O, benzodiazepine receptor antagonists reduced the subjective reports of feeling high, but did not alter psycho-motor performance.[14]




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