Posted by desolationrower on April 5, 2011, at 20:57:35
In reply to Re: PEA in place of selegiline? » desolationrower, posted by Cydnie on April 4, 2011, at 9:10:13
> Hi! Thanks for writing back about the PEA. I took a small dose of selegiline, I can't remember what the starting dose is, but it was the first thing that had worked for me as an anti-depressant. But it caused a flare up because of some inflammatory properties (having to do with interleukin b, it's a lot of science, that while I don't fully understand, I had to stop taking it and was so depressed). On stimulants, I've done fanastically on adderall and vyvanse. Using them was the first time I was able to motivate myself to get out of bed, was so social, was taking care of my baby and actually having fun, and was not making those horrible critical comments to myself in my mind (in fact, quite the opposite! Was doing so well on it!) Someone had recently told me you can't use them as an AD (I don't use just them, but it's amazing what an AD effect they've had for me, and I credit them for being the reason I've pulled myself up and out of my depression enough to get my baby and myself out of the house and go to a playgroup and talk to other moms, and my son could play with other kids).
they used to be called antidepressants when you could buy them in the drug store for whatever.
In animals models, they aren't antidepressants.
This isn't really the same as saying they don't help people with depression:
animal models usually involve torturing the animal, and seeing if it gives up on life. So, ADs give them the mouse equivalent of inner peace, acceptance of life sucking, etc. Animal models don't include the systemfuction of "change behaviour -> get better reactions from others and life in general -> life sucks less -> don't feel so depressed"
>Anyway, I know I can't use them forever,
the focus effects is pretty lasting. the mood and fire-under-ass effect less so.
>and a very small dose of remeron seemed to be working wonders along with adderall and vyvanse,
a very small dose of remeron = an antihistamine. probably improved sleep quality.
>but know I need to stop taking stims and go natural, so thought I should look at PEA. I saw that selegiline works on dopamine and phenylanine and so I was hoping to recreate the effect naturally hoping to bypass the allergy problem! (by the way, my doctor is very unusual and never made me stop taking stims with selegiline or emsam, never had one problem - but that was me) I thought if I used velvet bean/mucuna pruriens (15%) and l-phenylanine, maybe I could try. I read last night to use phenylanine and to have it work, you need an MAOI-B, like selegiline, so I looked for other suggestions for natural ones, and found kava listed, and am going to take it with green tea.
to me, kava was sort of similar to alcohol. this may help with anxiety or lack of energy for interactions. For MAOI level doses, i would expect strong anxyolytic effect, probably sleepiness. and i mixed it in green tea. it sort of tasted ok. since then, i read a series of books that posited a society that favored kava in coffee. I'm not sure that would taste good. i think rhodiola is also a MAOI. I think PEA is more of a AMP substitue with a MAOI, not a maoi substitute.
have you considered a regular old fashioned MAOI? tranylcypromine is the best AD i took, by far.
>I ordered it last night, so it will take awhile before I can start my experiment, but in case anyone's interested, I will definitely post back and let you know if it works! If you have any suggestions, desolationthrower, I would be so happy to hear them (or any questions). Thanks!! Cydnie
well hope it works out, let me know.
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