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Re: Why does Wellbutrin cause rage/irritability? Joe Schmoe

Posted by Conundrum on November 16, 2010, at 10:00:57

In reply to Why does Wellbutrin cause rage/irritability?, posted by Joe Schmoe on November 16, 2010, at 6:58:47

It seems to be very common to wellbutrin. Like you said there are no pure DRIs so its hard to say whether the dopamine is having this effect or not. Some times some drugs just make some people grumpy. lol. Vague I know. People get angry on alcohol or cocaine. Some get angry on wellbutrin. THe thing about wellbutrin is besides its effects as a DNRI it works on nitric oxide pathways and nicotinergic receptors. It does many things and it would be impossible to pin down what is causing what. So it would be best to try something else and not analyze why wellbutrin failed. If you try an NRI and have the same response then it could just be you don't need more norepinephrine.

> I have read Wellbutrin raises both dopamine and norepinephrine activity.
> I am just curious which of those is responsible for the common rage/irritability/short temper effects, or whether it is some combination of both.
> Kind of an academic question for me since it appears pure dopamine reuptake inhibitors are not legal here in the U.S. :(
> Or are they? I have read that Europe has some pure dopamine AD agents not available here, but on the other hand, aren't stimulants basically dopamine activity increasers?
> As someone with anxiety I have never even considered stimulants as a treatment for depression.

Complaints: post-SSRI problems: anhedonia, memory and concentration problems, sexual dysfunction. )
Currently taking mirtazapine, tianeptine, and SAM-e




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