Posted by tensor on April 5, 2010, at 12:48:52 [reposted on April 6, 2010, at 17:33:05 | original URL]
In reply to Technical question on new anti-depressant, posted by Katgirl on April 5, 2010, at 10:14:43
Hi,
I know mirtazapine possesses 5HT3 antagonist action and as far as I know it helps with nausea or other gastrointestinal problems.
Buspirone is a 5HT1A partial agonist, the theory behind such drugs is that they allow repletion of serotonin in neurons. If an SSRI is used but the the neurons are depleted then the SSRI would have no effect since there is no serotonin around anyway. Thus, adding a 5HT1A partial agonist could in theory make an SSRI effective and/or more effective./Mattias
> Hi all you super smart med "techies"! A new medication has finished up trials, and I'm hoping it may be out next year. It is identified as LU AA21004 and is a 5-HT3 antagonist and 5-HT1A partial agonist. Can you tell from that how it would be different from, say an SSRI (which I can no longer tolerate). Or what kind of side effects it might or might not have? Or just any insight of how it would work, would be appreciated. Thanks! Katgirl (who is still white knuckling it through life without a medication)
poster:tensor
thread:942527
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/942529.html