Posted by bleauberry on March 14, 2010, at 18:38:40 [reposted on March 15, 2010, at 0:42:42 | original URL]
In reply to For PURE Dopamine effect without Noradrenaline ?, posted by Mikez on March 13, 2010, at 0:51:49
I respond well to NE, but I have a skin condition that responds very badly to it. From that I can tell what is working on NE or not.
Amisulpride I think might indirectly boost NE a tiny bit, since some dopamine is metabolized into NE. But from my own trials, I would say it is almost pure dopamine, with a slight sense of maybe some background opioid connection somewhere. It has also been recently discovered to be a 5ht7 antagonist, though they aren't sure whether that is part of its therapeutic effect or not.
Stimulating at first, then stimulating yet relaxing simultaneously, with interest in things and a brighter outlook on everything, more engaging, more talkative, yet relaxed...that's how I would describe what amisulpride does to me. I think it is a good antidepressant, anti-anhedonia, pro-social, anti-anxiety, all in one.
But the size of the dose is what matters. It takes a little experimenting. For me, 25mg fell just a wee bit short, while 50mg was a bit overkill. So with 200mg tabs I powdered them and made custom 33mg doses. With too high of a dose you'll feel some dopamine antagonism beginning to happen. Not a bad thing, just maybe someone wants it or doesn't want it.
I would personally steer clear of the dopamine agonists. They seem to be good for restless legs syndrome in tiny doses, but rather problematic for everything else. That's just based on everything I have read. The few times I tried them I thought they felt depressing and aweful.
Abilify in a very low dose 1mg - 5mg might be a contender for you. It seems to go well with ssris but not that many good reports mixed with anything else or monotherapy.
poster:bleauberry
thread:939473
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/939607.html