Posted by conundrum on February 11, 2010, at 14:09:47 [reposted on February 21, 2010, at 13:24:09 | original URL]
In reply to Re: Fluoxetine(prozac) is a 5-HT2A antagonist., posted by Laney on February 11, 2010, at 13:28:24
I am trying 5mgs every other day again, because at this dose it did help with motivation. Unfortunately I waited about a week and increased to taking 5 mg everyday. Then I started to feel even less motivated than before. For prozac with me now, less is more. In fact I'm thinking of taking even smaller doses. I may try 1mg or .5. I found this interesting post about microdoses of prozac. The guy who wrote this made an error with one of his calculations and mentions it in a last post. But it is interesting that he still feels an effect at this dose.
http://www.imminst.org/forum/index.php?showtopic=26058
>>>>>>>>>>>>>
1mg normal ssri effects but milder than full dose (amotivational and a I downt realy care feeling)
0,5mg the same as 1mg but the sexual becomes milder
0,25 very optimistic feeling (euphoric if combinated with coffee/cofffeine)0,06 to 0,01 only effects are a optimistic state of mind
0,02 to 0,06 optimistic feeling and a litle unfocused minddoses below 0,1 are a litle sedative
doses from 0,25 and up are a litle more stimulating
>>>>>>>>>>>The thing I don't understand is how I was able to function perfectly well on 20mgs and now I can't tolerate 5mgs.
If this doesn't work I would like to try a tricyclic with NRI properties. I will probably have to take an SNRI first, but I'm scared of the withdrawals from those drugs and I think they would be too serotenergic. Its like my brain is saying stop! No more serotonin!!!
SERT means Serotonin Transporter. It is the protein that brings serotonin back into the nerve cell and the protein that is blocked by SSRIs to increase serotonin. At lower doses prozac doesn't block enough SERT to increase serotonin a lot, but it does hit some other spots in the brain that can give other effects. We will see how that pans out. Wish this crap worked faster though.
poster:conundrum
thread:937575
URL: http://www.dr-bob.org/babble/neuro/20091104/msgs/937584.html