Posted by Phidippus on November 17, 2009, at 19:06:50
In reply to Re: calling all armchair psychs » Phidippus, posted by conundrum on November 16, 2009, at 9:12:41
> When you say it modulates glutamate, does it increase it or decrease it?
Dextroamphetamine does not alter glutamate levels in the prefrontal cortex. This may be because dextroamphetamine increases dopamine release in the prefrontal cortex; activation of the dopamine-2 receptors inhibits glutamate release in the prefrontal cortex. However activation of the dopamine-1 receptors in the prefrontal cortex, increases glutamate leves in the nucleus accumbens. An increase of the glutamate levels in the nucleus accumbens may be part of the reason that dextroamphetamine has an ability to increase locomotor activity in rats. Serotonin may also play a role in dextroamphetamines affect on glutamate levels.
poster:Phidippus
thread:924919
URL: http://www.dr-bob.org/babble/neuro/20091104/msgs/926075.html