Posted by undopaminergic on August 10, 2008, at 21:59:18
In reply to Re PEA/selegiline » undopaminergic, posted by christophrejmc on July 16, 2008, at 7:44:43
I used a solution of PEA and regulated the intake according to effect - perhaps a mouth full or two every 10-20 minutes. The precise consumption was never determined, but it also varied. In the beginning, there were distinct cardiovascular effects even of small amounts - the heart rate would drop from 75-70 bpm to under 60 due to the baroreflex triggered by the increase in pressure - probably up to 160 systolic and higher. Chronic consumption blunted the hypertensive effect to the point where blood pressure was normal while taking PEA and on the low side in its absence. (I wasn't taking memantine.)
It's interesting that you've found PEA more potent than the other sympathomimetics. It should be less potent from a cardiovascular point of view than at least tyramine. amphetamine and ephedrine, but more potent than methylphenidate amd cocaine.
> How often were/are you taking PEA, and how much?
>
> I've been using this combo off and on for about four years but I haven't been able to find a dose that's both effective and safe. I've combined a lot of proscribed sympathomimetics with MAOIs, but only PEA has caused severe hypertensive events.
>
> > Yes, precisely. I speculate that PEA+deprenyl+memantine might hold some promise for more sustained effect, based on the observations made by others concerning prevention of amphetamine-tolerance by memantine.
> >
>
poster:undopaminergic
thread:834804
URL: http://www.dr-bob.org/babble/neuro/20080706/msgs/845458.html