Posted by Crotale on July 5, 2008, at 0:52:04
Hi. Some years back (when I was still in school) I did a paper on augmenting ADs with pindolol, a type 1a serotonergic autoreceptor antagonist (and beta blocker, but that's not the important part). At the time the evidence wasn't conclusive, but since then there has apparently been more research, some of which suggests that pindolol both accelerates the action of SRIs and augments their efficacy. Has anybody here tried this? (pindolol + SSRI, pindolol + mixed RI, etc.)? I don't think it would be effective with a SNRI (selective norepinephrine RI), and I suspect it would be dangerous with an MAOI. (autoreceptor antagonists cause the NT to be released extracellularly; that's why alpha-NE autoreceptor agonists, like clonidine and guanfacine, are used for treating ADHD; they're also used to treat opioid withdrawal symptoms in drug addicts.
poster:Crotale
thread:838118
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/838118.html