Posted by undopaminergic on June 30, 2008, at 14:29:29
In reply to Re: beta2- and beta3-adrenoceptors » undopaminergic, posted by Horned One on June 29, 2008, at 11:12:16
> I remember someone at work taking salbutamol tablets for severe asthma. I don't think it had the effect you were hoping for based on the pharmacology. It made her extremely nervous, agitated, jumpy, almost to the point of having a movement disorder. Her face and neck muscles used to jerk uncontrollably. She also had a severe hand tremor. In short she looked and acted like a speed freak. Ironically I was taking amphetamine at the time and had the same sort of tremors.
>
> I don't know whether it altered her mood, but I couldn't help but notice her overwhelming anxiety and restlesness.
>
> -HornyI was aware that these drugs often produce some tremor and nervousness that are most pronounced upon initiation of use and diminishing in intensity with continued treatment. The case you described seems more extreme.
Although in certain cases, salbutamol or another beta2-agonist might be sufficient as monotherapy, that seems very unlikely in more refractoy cases, where such a drug might be a useful sdjunct.
My plan is to test whether beta2-agonists can render precursor amino acids effective. Most of the precursor amino acids I've tried have had very little - if any - effect, and the rest produced little but adverse effects. I wonder if, for instance, salbutamol + L-dopa, or salbutamol + tryptophan would be more useful than the amino acids alone?
poster:undopaminergic
thread:836314
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/837335.html