Posted by undopaminergic on May 1, 2008, at 6:43:55
In reply to Re: Lamictal and melanin binding » bulldog2, posted by Quintal on April 28, 2008, at 9:56:42
> My problem is that all of the mood stabilizers are highly toxic, and lamotrigine is probably the one with the least side effects. Lithium causes thyroid and kidney damage, valproate has loads of side effects, as do carbamazepine and topiramate. I will probably just have to sick it out for now, but it's disconcerting to think it may be causing long-term damage that I don't know about.
Have you tested whether SSRIs work as mood-stabilisers? What about serotonin precursors (tryprophan and 5-HTP)? Omega-3 fatty acids? Combinations of several mood-stabilisers at tolerable, non-toxic doses?
Speculatively, vinpocetine may be effective as a mood stabiliser, as it antagonises voltage-gated sodium channels, similarly to anticonvulsants, including carbamazepine and lamotrigine. As a bonus, it enhances cerebral and retinal blood flow.