Posted by brot on January 16, 2008, at 9:27:27 [reposted on January 19, 2008, at 13:05:42 | original URL]
In reply to Re: does Seroquel interact with Tegretol?, posted by brot on January 16, 2008, at 9:18:40
> yes, they interact. Seroquel decreases the metabolism of a carbamazepine metabolite (active one). I take both but quite low dosage. Simply because they both help me and I dont know an alternative. (trileptal is crap)
>
> Just be aware that you can "overdose" on one tegretol metabolite if you take Seroquel.1: Pharmacotherapy. 2002 Nov;22(11):1500-3.Links
Elevation of carbamazepine-10,11-epoxide by quetiapine.
Fitzgerald BJ, Okos AJ.Fircrest Residential Habilitation Center, School of Pharmacy, University of Washington, Seattle 98155, USA. bfitz@u.washington.edu
A 52-year-old woman and a 56-year-old man who were receiving carbamazepine experienced markedly elevated levels of its active metabolite, carbamazepine-10,11-epoxide (CBZ-E), after starting quetiapine therapy. The CBZ-E:carbamazepine ratio increased 3-4-fold in each patient. Levels of CBZ-E returned to baseline after discontinuing this drug combination. The metabolite can accumulate and cause neurotoxicity. The woman experienced ataxia and agitation while receiving quetiapine, which resolved after carbamazepine was switched to oxcarbazepine. The man was asymptomatic. To our knowledge, these are the first two case reports describing this interaction. Quetiapine may inhibit epoxide hydrolase and/or glucuronidation of carbamazepine-10,11-trans-diol in the same way as valproate and possibly lamotrigine do. If carbamazepine and quetiapine are administered concurrently, clinicians should consider monitoring CBZ-E concentrations.
PMID: 12432977 [PubMed - indexed for MEDLINE]
poster:brot
thread:807667
URL: http://www.dr-bob.org/babble/neuro/20080114/msgs/807671.html