Posted by Phoenix1 on January 14, 2008, at 0:27:32 [reposted on January 16, 2008, at 2:32:09 | original URL]
In reply to Re: Help please: MAOI's + Grapefruit juice? » FrequentFryer, posted by Larry Hoover on January 12, 2008, at 11:25:11
> > Hi.
> > I am going to take some Temazapam to help me sleep but I have a HUGE tollerance to Bezodiazapines so hence I want to drink some Grapefruit juice beforehand so the Temaz actually works.
> > Thing is I am taking Nardil and dont know how the Grapefruit juice will effect the MAOI.
> >
> > Anyone know what kind of reaction Grapefruit juice and an MAOI would have?
> > Good, Bad, Ugly?
>
> Temazepam is the product of 3A4 acting on diazepam. It would be unaffected by grapefruit. Grapefruit would have no effect on Nardil metabolism. Your plan is not going to help, methinks.
>
> Lar
>Here's an interesting one. (BTW, I take Nardil and grapefruit juice seems to do nothing) But, I just got a prescription for Biaxin for a sinus infection (claithromycin). I take zopiclone (for Americans think eszopiclone). Clarithromycin is a potent inhibitor of CYP3a4 that metabolizes zopiclone. So I would exect an increased effect on the zopiclone? The pharmacist gave me a vacant look and said the computer didn't point out an interaction when I brought this up. She would rather that I didn't bring up any questions unless the answer is in the computer. So much for the helpful old-time pharmacist. Your thoughts? )on the clarithromycin-zopiclone interaction thing)
Phoenix1
poster:Phoenix1
thread:806889
URL: http://www.dr-bob.org/babble/neuro/20080114/msgs/806899.html