Posted by Phoenix1 on January 12, 2008, at 23:23:42 [reposted on January 15, 2008, at 3:30:53 | original URL]
In reply to Re: Nardil: My Experience Thus Far.... » Phoenix1, posted by tecknohed on January 7, 2008, at 20:37:00
> > Was there ever consensus on whether getting Nardil enteric coated (by a compounding pharmacy or using Plasminplus) increased the effects/bioavailability?
> >
> > Phoenix1
>
> Dont know. I doubt it. Apart from within the walls of the pharmaceutical companies of course LOL.
>
> I wasn't saying that I dont believe the new/old Nardil problems people have are real, incase that is what you thought I was implying.
>
> UK Nardil literally melts in the mouth so its coating simply holds the contents together. I often sucked on mine (I grew to love the taste) & loved its smell. It was the most powerfull pharmaceutical drug I've EVER taken, so obviously in my case no enteric coating was necessary. Have you any ideas why Nardil was given an enteric coating (if thats what happened)?
> Perhapse it was a way to avoid refridgeration? I guess its well absorbed as a sulphate?
> What salt is bound to phenelze in Pfizer's new formula? Would Nardil not work as a hydrochloride salt? I always found Nardil felt more potent with a quicker aborption when taken right at the start of a meal, when hydrochloric acid would be at peak stomach concentrations.
> But to be honest I have no idea why different drugs are bound to different salt. Maybe each drug has its own most absorbable salt form. Maybe its to do with stability. Or both.
>
> By the way, what is Plasminplus & what is it meant to do? Is it a type of coating or something?
>
> teckHi Teck,
I also don't know if th new/old Nardil complants are valid snce I've only used the new Nardil and it seems quite effective. I don't doubt that some people eperienced difficulties during the changeover, but it's hard to pinpoint what the cause might have been.
If you look bck a few years in the archives, people were postulating that the "new" nardil was dissolving too quickly in the stomach and that is hat accounted for reduced effect for many and increased side effects. People thought that one of the removed excipients (I forget which one) acted as an enteric coating slowing the dissolution of the tablet and allowing more to be absorbed in the intestine rather than the stomach. The idea was that if you enteric coated the new Nardil, it would act more like the old Nardil. One poster bought a product called Plasminplus which comes in enteric capsules and emptied the capsules and then put the Nardil in.
Not sure if this was effective, but it's an expensive way to go if you are taking 6 Nardils a day like I plan to.
Do compounding pharmacies enteric coat meds on request?
Phoenix1
poster:Phoenix1
thread:806637
URL: http://www.dr-bob.org/babble/neuro/20080114/msgs/806637.html