Posted by Larry Hoover on December 26, 2015, at 13:14:08
In reply to Re: What is a good vitamin D3 maintenance dosage? » Larry Hoover, posted by SLS on December 25, 2015, at 16:49:39
> > Vitamin D3 supplementation should be adjusted on the basis of body weight.
> >
> > http://www.ncbi.nlm.nih.gov/pubmed/22262154
> >
> > Not shown in this abstract, but one of the authors (Dr. Heaney) said the formula to obtain 25(OH)D levels of >40 ng/ml is 70-80IU/kg/day. (35IU/pound/day). So, a 200 lb. person should take 7000IU/day, as a simple example.
> >
> > Lar
>
> Thanks.
>
> I've been taking only 5000 IU per day. I think I'll raise the dosage. I would need to take 7000 IU/day or 50,000 IU per week. Is it possible to take 50,000 IU as a single dose on a weekly basis? Would there be any negative consequences to taking 10,000 IU/day.
>
> Thanks again.
>
>
> - ScottI've been expanding my research parameters on the subject, and it's really quite fascinating. For example, the Institute of Medicine's daily recommendation of 800 IU/day is the result of a math error (proven by another team reviewing the same database). It was a decimal error, suggesting the recommended daily intake (all sources, not just supplements) should be >8000 IU.
Anyway, on to your questions. Individual response to D3 supplements is quite variable, so the equation provided above should be seen as first pass guidance. The only way to know if you're achieving the desired target of 40 ng/ml 25(OH)D is having your blood tested. Given that you have been taking a stable dose for a period of time, maybe a blood test would be a good place to start?
Yes, you can take your D3 supps in bolus (single high dose) form, but for people like me, I do better with a daily routine. I'd forget when I did it, and when the next dose should be.
No, there would not be any expected consequences of taking 10,000 IU/day. You'd still be far below the potential for adverse events. And, for the record, the most obvious adverse events arising from hypervitaminosis D3 (D3 excess) are not caused by D3 at all. As you increase your intake of D3, you increase your need for vitamin K2. Ultimately, D3 excess causes K2 deficiency, and those deficiency symptoms have traditionally been blamed on the D3 excess.
I'll see if I can find a proportionality chart for D3 and K2.
Lar
poster:Larry Hoover
thread:1079304
URL: http://www.dr-bob.org/babble/alter/20150301/msgs/1084989.html