Posted by Tomatheus on November 24, 2015, at 11:54:56
In reply to Methylfolate and negative Schizophrenia symptoms, posted by Lamdage22 on November 24, 2015, at 11:06:51
Lamdage,
I found one study where participants with either major depressive disorder or schizophrenia were administered 15 mg/day of methylfolate along with their medications over a six-month period. The study's abstract (http://www.ncbi.nlm.nih.gov/pubmed/1974941) doesn't mention how well methylfolate was tolerated, but the methylfolate was reported to have significantly improved clinical and social recovery in the participants with depression, as well as the participants with schizophrenia.
I think it's possible that l-methylfolate could conceivably worsen symptoms in a subset of patients with psychotic disorders. I took l-methylfolate years ago and didn't notice any problems with 800 mcg, but I recall noticing a slight worsening of one of my symptoms when I tried taking 2.4 mg. So, I don't know. I'd say that a worsening of symptoms is always something that could happen when trying a substance that you haven't tried before, but I don't think that the likelihood of that happening with methylfolate is very high, especially given the large doses of antipsychotics that you're taking and the fact that methylfolate only seemed to produce improvements in patients with schizophrenia in the study that I referred to above. I know that in my case, when I start taking a new supplement, I tend to use low doses at first and then increase the dose later on, depending on how well I tolerate the lower doses. That approach might be worth considering.
Well, I wish you luck finding the best treatment for you.
Tomatheus
"I need you to show me
The way from crazy
I wanna be so much
More than this"- Jimmy Eat World
poster:Tomatheus
thread:1084175
URL: http://www.dr-bob.org/babble/alter/20150301/msgs/1084177.html