Posted by alexcanada on March 15, 2013, at 22:56:31
In reply to Re: SAM-e and phosphatidylcholine » alexcanada, posted by Tomatheus on March 14, 2013, at 11:11:48
Hi. Thanks for the response. I don't know yet what effect D3 is having on me. I only took it for a few days and I skipped it today thus far. I was def more alert a few hours after taking it but usually I feel more alertness late in the night away. It might be too soon to tell and especially since my mood can fluctuate quite a bit during the day anyway. Tonight I am quite tired without it so perhaps I will take one and see.
> Hi Alex,
>
> My experiences with SAM-e have generally been positive, but I think that there's some uncertainty as to whether it may have contributed to the onset of my psychosis and cognitive impairment when I took it with tranylcypromine (generic Parnate) more than six years ago. Before the onset of my psychosis, I found SAM-e to be beneficial in the treatment of my chronic fatigue, or vegetative depression, in a significant way. It gave me more energy, allowed me to think more quickly, and reduced my excessive need for sleep, but the most pronounced of these benefits only lasted for three days before fading. I continued to notice some lower-level benefits from SAM-e on the symptoms that I mentioned when I took it with tranylcypromine, but three months into my trial with this combo is when I suddenly went into a psychotic state with cognitive impairment. I now take Abilify for my psychosis, and the vitmain D3 that I'm taking might be helping a bit with my cognition, but basically, the cognitive problems and psychosis are problems that I have not recovered from. Whether the tranylcypromine and SAM-e I took when I went into my cognitively impaired psychotic state caused the psychosis and cognitive problems is uncertain. At one point, I attributed the psychosis and cognitive problems to aminoguanidine that I took, thinking that I took the aminoguanidine right before the onset of the psychosis and cognitive impairment. However, after reading some old e-mails I had written when I was taking tranylcypromine and SAM-e (and aminoguanidine), I realized that I actually took the aminoguanidine about a month before my psychotic and cognitive symptoms surfaced, and so I concluded that the medication probably isn't what caused the symptoms to surface.
>
> At any rate, I have tried SAM-e since the onset of my psychotic symptoms. Strangely enough, taking enteric-coated SAM-e tablets doesn't seem to have any effect on me any more, but crushing up the tablets and taking them sublingually (which tastes horrible) does. Now, it seems that I notice improvements in my energy level from taking sublingual SAM-e that last for about a week before the supplement seems to lose its effectiveness. So, I've actually responded to SAM-e differently after the onset of my psychosis than I used to before the onset of my psychosis in the sense that the duration of the benefits that I notice is different, but it's still basically the same effect of having more energy.
>
> I'm really not sure how SAM-e might interact with the medications and supplements that you're taking, but my experience has taught me to be cautious with it. I certainly wouldn't take SAM-e with an MAOI anymore. I don't know if I'd take it with the medications and supplements that you're taking, either, as I think it would be hard to say what kinds of effects you might notice if you were to add SAM-e to your combo.
>
> I have taken resveratrol, and I recall noticing some short-lived benefits on the symptoms of my chronic fatigue, or vegetative depression, but not staying on the supplement for very long. I think that resveratrol might be one of a few supplements that I'd benefit from revisiting.
>
> Finally, I have a question for you. I noticed that you've said that you're taking vitamin D3, which is something that I just started taking and seem to be benefiting from (as far as my energy, concentration, and hypersomnia are concerned) at this point in time. Do you think that you've benefited at all from taking vitamin D3 so far? Have you ever had your vitamin D levels measured in a blood test? I did recently, and my level came back low.
>
> Tomatheus
poster:alexcanada
thread:1035191
URL: http://www.dr-bob.org/babble/alter/20120530/msgs/1040432.html