Posted by SLS on August 2, 2012, at 12:42:58
In reply to any way to calm down DA/NE?, posted by g_g_g_unit on August 2, 2012, at 7:21:40
> Long story short .. been on 60mg of Parnate for some time now and just finding it too stimulating (i.e. no benefits on anxiety, chronic insomnia, etc.). I've heard higher doses can be more calming, but my p-doc won't prescribe anymore.
> Anyway, I'm taking 1.5mg of Klonopin at night to sleep, and 0.5mg in the morning, but it still isn't really sufficient.. the stimulant effect of each dose is meant to have a 2.5 hour half-life, so I take 15mg every 3 hours, but just find that there's a cumulative effect that leaves me feeling kinda wired, confused and unable to focus properly.
> I'm planning to taper off it, but I really need to be able to concentrate on a project over the next week. Lowering the dose probably wouldn't help, because there'd be a lag between the stimulant effect and MAO levels, which would just end up messy (I tried this for several days).
> Is there anything I could take to kind of put a 'cap' on DA/NE? Would NAC work for this? Tried magnesium, but it just potentiated the stimulant effect.
NAC is a good guess. It was the first thing that popped into my head as I began reading your post. You might be experiencing overactive glutamate circuits secondary to NE activation. NAC dampens glutamate hyperactivity. It is certainly worth a try. NAC is a rather benign substance. I tried it, but I felt more depressed during the first week. I discontinued it at that point. Looking back on it, my worsened state could have been the natural course of my illness. I never rechallenged myself with it. NAC might be a good adjunct to Lamictal, another glutamate suppressant. A friend of mine is currently trying this combination along with low-dosage Abilify.
Some see things as they are and ask why.
I dream of things that never were and ask why not.
- George Bernard Shaw