Posted by SLS on May 20, 2012, at 5:07:42
In reply to Flowering Quince: dopamine reuptake inhibitor, posted by psychobot5000 on May 14, 2012, at 16:56:29
> Hello, all.
>
> So, it seems that extract of flowering quince selectively and potently inhibits the dopamine transporter:
> http://www.ncbi.nlm.nih.gov/pubmed/18485464
>
> It's being looked into for parkinson's disease, and Chinese medicine uses it for depression. Thoughts on this, or on how to get ahold of such an extract or powder for use in, say, depression or ADD? A selective dopamine reuptake inhibitor that's available for the asking is a rare and possibly useful find.This is a total guess, but adding desipramine, a NRI TCA, to the Quince might produce a more stable antidepressant response. I am basing this on the therapeutic properties of nominfensine, a DRI/NRI. Once sold under the trade name, Merital, it helped some people who were otherwise TRD. It is the only drug they ever responded to. Unfortunately, it was withdrawn from the market worldwide due to the emergence of a rare occurrence of hemolytic anemia. I get the impression that nomefensine was more effective than amineptine, a selective DRI. Anyway, if the Quince gives you transient improvements - much like amphetamine would - you might think of it more as an augmenter of antidepressants than a core treatment. However, if I were you, I would continue your experiment with Quince monotherapy unless intolerable physical or psychiatric side effects emerge. How long were you thinking of giving it? Six weeks?
While it is on my mind, have you ever tried low-dosage lithium (150 - 450 mg) as an augmenter?
Co-Q10? - allows the body to more effectively utilize ATP energy.
NAC? - produces glutathione, an neural antioxident.
Alpha Lipoic Acid? - produces both of the effects described above.
Deplin (L-methylfolate)? - helps the body manufacture neurotransmitters. It also lowers homocysteine levels to promote cardiovascular health.
Please report the results of your experiment. It would be valuable information.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1017886
URL: http://www.dr-bob.org/babble/alter/20111229/msgs/1018276.html