Posted by garnet71 on February 24, 2009, at 12:22:03
In reply to Re: Natural anticonvulsants? » desolationrower, posted by SLS on February 24, 2009, at 6:48:00
You would know the dynamics better than I, but serotonin acts as an inhibitor of many glutamatergic pathways. My guess is the sudden drop in synaptic serotonin as a result of removing an SRI disinhibits these glutamate pathways and allows them to become hyperexcitable and leading to kindling. I think the kindling allows for the withdrawal severity to grow more intense over time, prevents some people from discontinuing entirely, and allows for a persistence of withdrawal symptoms long after the drug is discontinued. I also have a hunch that future withdrawal episodes from discontinuing successive SRIs produces more severe withdrawal syndromes.
- Scott--------------------------
What are glutamatergic pathways and kindling? I'm not sure I'm understanding what you all are saying here--Could this be related to those of us who have had chronic and severe anxiety after discontinuing these drugs that were initially prescribed for a severe depression? Esp. for those of us who never had this problem pre-xxRI?
Could that explain why these drugs haven't worked/treatment resistance? (Common sense - If the drug (discontinuating effects) has caused the problem, how can it be expected to correct it?)
poster:garnet71
thread:881348
URL: http://www.dr-bob.org/babble/alter/20090204/msgs/882173.html