Posted by Larry Hoover on March 25, 2007, at 17:34:39
In reply to Re: nutrients » Squiggles, posted by Larry Hoover on March 25, 2007, at 11:42:58
> And why is toxicity such an issue? The RDA and its successor DRI both are defined in terms of clinical deficiency. Based on the mean intake level at which 50% of subjects demonstrate *overt* clinical symptoms of deficiency, they then go two standard deviations upwards, and hit the 95th percentile.
Ooops. Should read 97.5 percentile. Two standard deviations contain 95% of the population, but 47.5% of that is on either side of the mean. The 1 out of 40 (2.5%) showing overt symptoms was correctly stated.
Lar
poster:Larry Hoover
thread:744072
URL: http://www.dr-bob.org/babble/alter/20070320/msgs/744181.html