Posted by aeon on November 23, 2006, at 22:02:35
In reply to Is there a connection - SAM-e -- Glutathione??, posted by Jimmyboy on November 23, 2006, at 18:45:31
Hi
I don't know about S-ame - there seems to be so much disinfo about its effects and the methylation pathway is so complex that it is easy enough to implicate just about anything with it. From what I can read there is little real evidence that increasing S-ame will increase glutathione, it is a theoretical thing maybe. If someone could help me out with in vivo studies I am open to it. But if you are feeling better and can afford the stuff then maybe...
However in regards to Glutahione specifically you could probably get more bang for your buck by using R-Lipoic Acid instead. It specifically saves the glutahione you have from being used up quite so much.
B12, P5P (Pyridoxal 5-Phoispate an active form of B6, and super high doses of folic acid (in the realm of 5 mgs) would add nicely to the R-Lipoic Acid and pine bark. High doses of Folic acid are very stimulant-like - I have seen studies for its effects in ADHD symptoms in Fragile X syndrome and have been experimenting with them and won't go back to lower levels because I need the stimulation. I am hoping it will be my answer to my ADHD sxs in high enough doses. (talking 10-20mg day here).
Up to 8% of the population have been found to have C677-T Polymorphism which basically means they lack the enzyme to convert folic acid to active metabolites efficiently and need many times the normal dose of folates. This results in a cascade effect of elevated homocysteine, reduced glutathione, reduced dopamine and NE, depression, Bipolar, ADHD, heavy metal buildup, heart disease and diabetes etc etc. They respond very well to high doses of folic acid.
BTW The N-Acetyl Cysteine *could* result in elevated acetylcholine levels which makes ALOT of people feel depressed. I have recently cut out all "Acetyl" products and feel less grumpy and irritable as a result.
Anyway don't know if that helps but I am very interested in this so please let us know how you go with your glutahione and how you feel!!
Cheers
aeon
poster:aeon
thread:706531
URL: http://www.dr-bob.org/babble/alter/20061118/msgs/706575.html