Posted by kiwiredbeach on November 17, 2006, at 7:55:40
In reply to Re: Fish oil and neurotransmitters, posted by aeon on November 17, 2006, at 6:25:32
Thanks aeon very interesting reply....you have given me something to think about, were do you get Quercetin ? from health food shop I imagine. I have had slight eczema, and asthma (in the family) and my father also suffers bad arthritis at a older age. He took vioxx for great success untill they took it away. Are these signs of cox2 behaviour.
Cheers kiwi
PS great to have you here Aeon> > How does fish oil effect neurotransmitters, im taking a high epa fish oil which seems to work really well for depression, but has increased my anxiety a notch. How does epa effect norepinephrine and serotonin or does it work in a completly different way to effect depression and anxiety
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> Hi
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> Thanks for the welcome! There's a whole lot of poor around about fish oil. It really has no DIRECt effects on neurotransmitters. There is some evidence that it may stabilise the nerve membranes but i tell you if you had unstable nerve mebranes you would no all about it and depression would be the last of your worriies.
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> The main beneficial effect of EPA for depression arises (in my opinion - supported by years of research) due to it can inhibit to a certain extent the conversion of GLA to Arachidonic acid, which the body makes evil and bad inflammatory prostaglandins of the series 2 via COX2. PGE2's make you feel BAD, they are the sickness hormones and they lay you down and make you rest.
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> This effect is not complete though, and unless you are inhibiting COX2 you will not stop the aberrant inflammation that is causing the depression.
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> EPA also is converted to series 3 prostaglandins that have many health benefits (they are good guys. They attract oxygen for energy transfer and also make the adrenals work better - hence your slightly increased anxiety.
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> To really feel good you need to also increase the GLA (evening primrose oil, borage) so that the body has the raw ingredients it needs for series 1 Prostaglandings. I believe it is these ones that actually make the sensation of "I am well". If you only do the PGE2 you will feel more like "I'm not depressed as I was".
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> When the body is well it rewards you with increased serotonin etc, to make you get up and go!
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> Hope that helps somewhat.
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poster:kiwiredbeach
thread:704475
URL: http://www.dr-bob.org/babble/alter/20061013/msgs/704487.html