Posted by Larry Hoover on June 9, 2006, at 12:00:55
In reply to Re: You could be histadelic » Larry Hoover, posted by dessbee on June 9, 2006, at 9:37:15
> I am pretty sure you already know this.
> GLA can be transformed into PGE1 and PGE2.
> PGE1 is anti-inflammatory, PGE2 is inflammatory.
> The best way to block PGE2 formation is through competitive inhibition with EPA (fish oil fatty acid) since GLA and EPA uses the same enzyme.
> EPA uses this enzyme for PGE3 formation, another anti-inflammatory prostaglandin.The thing I was trying to get out is that the answer you gave was correct or incorrect, depending on these other things.
In an omega-3 deficient state, particularly one deficient in EPA, the massive intake of omega-6 PUFAs we get with all the vegetable oil that is flooding the food chain (industrial food supply) goes on to become inflammatory prostaglandins, via arichidonic acid.
To make GLA a good choice though, you have to block the fatty acid from the enzyme that would take it to arichadonic acid. You just lose the benefit altogether, that way. In fact, you promote the formation of free arichadonate. You want the GLA to go dihomogammalinolenic acid, instead. The anti-inflammatory precursor.
I thought your post was incomplete because you didn't give the factors that govern the trend towards one outcome versus the other.
GLA is *not* contraindicated in North Americans, virtually for certain. It should be the assumed case. The general diet is shifted far far towards an inflammatory state already. GLA is definitely necessary, but you shouldn't begin taking it until you get your EPA stores replenished. Once you've been on fish oil for 2 or 3 months, GLA is going to get shunted into the optimal biochemical pathway. Before that enzyme gets blocked, though, GLA is inflammatory.
Lar
poster:Larry Hoover
thread:646450
URL: http://www.dr-bob.org/babble/alter/20060601/msgs/654834.html