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SAMe: Risk of Parkinson's?

Posted by honeybee on May 10, 2006, at 15:45:23

An article I uncovered about SAM-e says the following:

It has been cautioned that SAMe be avoided in patients with Parkinson's Disease. Animal Studies indicate that excessive methylation is associated with Parkinson's disease and SAMe excess has caused Parkinson's disease-like effects in animal studies. In addition both animal and human studies indicate that increased methylation can cause the depletion of dopamine and block the effects of L-Dopa. this line of research is contradicted, however, by preliminary evidence that SAMe may improve the emotional depression and the impaired mental function that is often associated with Parkinson's disease. Nonetheless, it is recommended that patients with Parkinson's disease avoid supplementing with SAMe until more is known.

How high a risk is there of Parkinson's in drugs that increase dopamine and/if there is this risk, then what happens when it happens. Reversible? Not?


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poster:honeybee thread:642256
URL: http://www.dr-bob.org/babble/alter/20060428/msgs/642256.html