Posted by Ktemene on September 25, 2005, at 13:56:55
In reply to I tried SAM-e, posted by JaneB on September 24, 2005, at 18:37:21
> I took 200 mg SAM-e one day and 400 the next. I couldn't stay awake. I felt like crying all day (not like me). What's up?
> I thought it would help joint pain and give me a mood lift. What a disappointment.Hi Jane,
Are you taking B vitamins as well? People who don't have enough B vitamins (particularly B6, B12 and folate) may not be benefited by SAMe and may actually have negative effects from it.
Insomnia and nervousness can be side effects of SAMe. The important thing is to listen to your body. If you think it is worthwhile, you might let a few days go by and then try SAMe again at a lower dosage. If the side effects appear again, then SAMe is not for you.
SAMe has been used for arthritis and there have been a fair number of clinical trials. I have coped the references for a few articles below.
Ktemene
Soeken KL, Lee WL, Bausell RB, et al. Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis. J Fam Pract 2002;51:425-30.
Konig B. A long-term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis. Am J Med 1987;83:78-80.
Berger R, Nowak H. A new medical approach to the treatment of osteoarthritis. Report of an open phase IV study with ademetionine (Gumbaral). Am J Med 1987;83:84-8.
Muller-Fassbender H. Double-blind clinical trial of S-adenosylmethionine versus ibuprofen in the treatment of osteoarthritis. Am J Med 1987;83:81-3.
Vetter G. Double-blind comparative clinical trial with S-adenosylmethionine and indomethacin in the treatment of osteoarthritis. Am J Med 1987;83:78-80.
Maccagno A, Di Giorgio EE, Caston OL, Sagasta CL. Double-blind controlled clinical trial of oral S-adenosylmethionine versus piroxicam in knee osteoarthritis. Am J Med 1987;83:72-7.
Caruso I, Pietrogrande V. Italian double-blind, multicenter study comparing S-adenosylmethionine, naproxen, and placebo in the treatment of degenerative joint disease. Am J Med 1987;83:66-71.
di Padova C. S-adenosylmethionine in the treatment of osteoarthritis. Review of the clinical studies. Am J Med 1987;83:60-5.
Glorioso S, Todesco S, Mazzi A, et al. Double-blind, multicentre study of the activity of S-adenosylmethionine in hip and knee osteoarthritis. Int J Clin Pharmacol Res 1985;5:39-49.
poster:Ktemene
thread:559129
URL: http://www.dr-bob.org/babble/alter/20050924/msgs/559434.html