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For those who feel MORE depressed w. magnesium...

Posted by Mistermindmasta on September 11, 2005, at 23:34:22

I have a little theory that might not have any truth to it, since I really don't know enough about neuroscience to be talking like I'm going to be talking, but I'll share it anyway. First off, let me explain some things about magnesium supplementation:

It is *thought* to be:

1. GABA A agonist
2. NMDA receptor antagonist
3. Calcium Channel Blocker

Some common reports that I see when people use magnesium are something like this..

- generally seems to be mildly sedating / relaxing
- sometimes induces depressive feelings / lethargic feelings
- sometimes induces feelings of well being

The issue here that some of the people here have with Mg is that it appears to sometimes have a rather contradictory ability to induce depressive feelings. I think this is due to the fact that Mg is an NMDA antagonist and a Calcium Channel Blocker. Blocking calcium channels lowers sympathetic arousal and norepinephrine levels. Acutely, this can make one feel kinda spacy, but in the long term, it appears calcium channel blocking has a mood stabilising effect. Antagonizing the NMDA receptor has anti-depressant effects but also tends to make one feel a little spacy at first - until the antidepressant effect kicks in... essentially, until the damage caused by excessive glutamate activity is undone.

I'm going to suggest the following, for the people who seem to get depressed from Mg use: maybe our bodies are so out of wack from being mildly magnesium deficient for so long that introcucing large quantities of magnesium totally disrupts the calcium channels and NMDA receptor activity - but theoretically / hopefully only for the first week or so until things re-regulate. Has anyone had the experience of magnesium kind of spacing them out at first but then have a mood leveling effect after a few more days?

It just seems so contradictory that magnesium causes depression and I really want to try to explain it away... there's just too much good evidence going for magnesium for me to think that its really not worth using.

I just started using Magnesium and I feel kind of out of it... like slow thinking, when I take too much (approx 400mg) at one time. I'm hoping this foggy feeling will go away or turn into a nicer feeling. What do you think? It definitely has acute anxiety reducing properties, just FYI... I definitely recommend it for that.


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poster:Mistermindmasta thread:554015
URL: http://www.dr-bob.org/babble/alter/20050812/msgs/554015.html