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Re: Nardil St John Wart » ace

Posted by Chairman_MAO on June 20, 2005, at 16:48:57 [reposted on June 22, 2005, at 20:47:50 | original URL]

In reply to Nardil St John Wart, posted by ace on June 19, 2005, at 23:04:11

Please try sublingual buprenorphine tabs, ace. Mu-opioid agonists have known, powerful anti-OCD and antidepressant properties. Buprenorphine is a kappa antagonist as well as a mu-agonist, which confers it with additional antidepressant and possible antipsychotic activity. You are, IMHO, wasting your time with SJW. Think about it: Nardil addresses in some way SE, NE, GABA, and DA. However, it only addresses DA via MAO inhibition, and since SE--which is "increased" as well via MAO inhibition--counterbalances DA, it still has a somewhat dopamine inhibitory action. Thus, another possibility you may find relief from is a dopamine agonist or psychostimulant. Instead of trying all these esoteric combinations, try to rationally break down what you have going on with the drugs you are taking. Try medications that address neurotransmitter subsystems and/or have mechanisms of action that are not currently in play.

NMDA antagonism also confers an antidepressant effect; thus you may try memantine or amantadine. They also induce DA release.


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URL: http://www.dr-bob.org/babble/alter/20050612/msgs/517250.html