Posted by Elroy on March 10, 2005, at 21:16:20
In reply to RE: LYRICA and the USA, posted by mogger on March 10, 2005, at 1:13:11
The DPLA - or at least the L-phenylalanine amino acid - is critical in this combination. The DPLA basically (and this is a real thumbnail sketch type of summarization) releases the dopamine and PEA and the (very low dose) selegiline simply keeps the dopamine and PEA active in the brain much longer than they normally would be. OEA especially has a very short half-life in the brain... something like less than a minute (unless the deprenyl is present).
Some people do better with one dose in the morning only. Others do better with half the dose in the morning and half the dose in very early afternoon. Not good to take it later int eh day only because it can be quite energizing and create some sleep problems if taken too late.
I have also read some material that also taking L-Theanine (during day), GABA (during the day), TMG (or samE "sammy", but TMG does the same thing cheaper) and 5-HTP(taking the 5-HTP on empty stomach at bedtime) all are also helpful in improving the effects of the deprenyl and creating a situation where brain neurotransmitters are balanced.
Find a copy of the book "The Edge Effect" by Doctor Eric Braverman and read it thoroughly for a much better understanding of the aspects of the brain's neurotransmitters, correcting deficiencies in brain neurotranmitters, and balancing and optimizing them.
I believe that it goes a long way towards explaining why SSRIs (serotonin) simply don't work on a lot of people or aren't that effective over the long haul. If one has a primarily GABA deficiency and mild serotonin deficiency then taking SSRI type ADs will provide a little help, but overall not much... which would only make sense since the GABA deficiency isn't being addressed!
The "Edge Effect" has a comprehensive test in it that you can take to pretty fairly determine your neurotransmitter dominance. And then another one to determine your neurotransmitter deciciecy (or deficiencies).
I took them and found that I had a dopamine dominant brain and primary deficiencies in Dopamine and secondarily in GABA with mild deficiency in Acetylcholine and almost NONE in serotonin.
So SSRIs wouldn't make much sense in my situation (and has NOT worked well the couple times tried), but the recently taken deprenyl / DPLA / B6 combination has worked wonders... as it should seeing as how there apparently was a serious dopamine deficiency!
Interestingly Xanax works thru GABA pathways, but I have recently (yesterday) been started on Neurontin for some neuropathic pain relief and it works even more strongly on the GABA system so may very well end up being able to wean completely off the Xanax while on the Neurontin.
Ideally - as Braverman discusses in his book - through proper supplementation via concentrated nutrients one can get to that state where deficiencies are corrected, and balancing and optimizing is going on... and meds can be either completely dropped or at least significantly minimized!
> Thanks so much for your thoughts, I will discuss it with her doctor. Are the amino acids critical or will she have positive effects even without the amino acids?
> mogger
poster:Elroy
thread:452259
URL: http://www.dr-bob.org/babble/alter/20050225/msgs/469457.html