Posted by jasmineneroli on February 8, 2005, at 0:41:14
In reply to Re: Is NADH available in Canada ?? » jasmineneroli, posted by Larry Hoover on February 7, 2005, at 8:02:41
Hi Lar: I believe it was enteric coated, but I actually gave them to my daughter, so I can't check for myself.
I did a search to see if Swiss Herbal mentions that, but only found the following. Since it refers to a change to NAD rather than NADH, I thought you might be interested:"Ingredients: NAD (Nicotinamide Adenine Dinucleotide) 2.5mg
Dosage: Take one or two tablets daily or as directed by a physician
Swiss recently changed the bottle to read NAD instead of NADH. NAD, known as Coenzyme 1, plays an important role in energy production. Swiss felt that NADH was less stable as a supplement than NAD. The following information is provided to explain the difference between NAD & NADH:
NADH is the abbreviation used for Nicotinamide Adenine Dinucleotide, one of the most important coenzymes in the human brain and body. A coenzyme is the active, or working form of a vitamin. NADH is the reduced (electron- energy rich) coenzyme form of vitamin B3, while NAD is the oxidized (burned) coenzyme form of B3.
NAD and NADH are converted into each other in numerous different metabolic activities. In some metabolic reactions it is NAD which is the needed catalyst, with NADH a useful by-product, in other reactions the situation is reversed.
NAD and NADH also serve to activate various enzymes, NAD for example, activates alcohol dehydrogenase and acetaldehyde dehydrogenase that are the two enzymes needed to detoxify the alcohol we drink into carbon dioxide and water.
NADH is the first of five enzyme complexes of the electron transport chain, where much of the ATP bioenergy that runs every biological process of our lives is formed.
NADH its vital chemical role:
As already noted, NAD(H) is the coenzyme or active form of vitamin B3. The chemistry of NAD(H) is some of the most complex in the human body. NAD(H) is necessary to oxidize (burn) all foodstuffs (fats, sugars, amino-acids) into ATP bioenergy. There are three interlinked energy production cycles: the glycolytic (sugar burning) and Krebs' citric acid cycles (aminos and fats are "burned" through the Krebs' cycle), and the electron transport side chain (ETSC).A glycolytic cycle "waste" end product- pyruvic acid- helps power the Krebs' cycle, while electron "sparks" released from the step by step slow "burning" that occurs in the Krebs' cycle provide the fuel used by the ETSC to generate much of the ATP bioenergy that literally powers our life. NAD(H) is involved in all of these different cycles, as well as in the conversion of the pyruvate end product of the glycolytic cycle into the beginning fuel of the Krebs' citric acid cycle. It is NADH, which captures the electron "sparks" thrown off during Krebs' cycle oxidation and shuttles them to the ETSC energy production cycle.
Each unit of NADH is capable of generating three units of ATP energy. In a very real sense, NADH is the "energy of life" coenzyme.
NAD, known biologically as coenzyme 1, is found in every cell in the human body, where it plays an important role in energy production in the cells. Cells require energy in order to perform their cellular processes efficiently. In every cell, glucose and oxygen are converted into energy, known as ATP. NAD is the 'spark' which drives this process, known as cellular respiration. A total of 10 NAD is required for this process. Any deficiency in NAD molecules reduces the cellular energy output significantly.
Where is NAD's Function Particularly Important in the Body?
Energy is constantly driving every cell in the human body. NAD's involvement in the brain, central nervous system and muscles, where it not only aids in producing cellular energy, but also stimulates production of the neurotransmitters, Dopamine, Noradrenaline and Serotonin. NAD is also involved in the body's immune system, where it functions as a powerful anti-oxidant and plays an important role in DNA and cellular repair and maintenance.
What Benefits may be Achieved by Supplementing with NAD?
NAD is an excellent dietary supplement for individuals whose lifestyles require more energy, vitality and improved mental alertness.
NAD's ability to improve overall cellular energy and elevate mental clarity, alertness and concentration initiated interest in current clinical studies relating to Depression, Chronic Fatigue Syndrome (CFS), Alzheimer's Disease, Parkinson's Disease and Athletic Endurance.
A clinical study presented by Forsyth et al, at the 1998 meeting of the American College of Allergy, Asthma and Immunology reported the results of NAD tested in a double-blind, placebo controlled study of patients with CFS. The results indicated significant improvement (ie. 73% over long term) in clinical symptoms and energy levels of CFS patients taking NADH.
Overall, NAD is a biological co-enzyme which increases energy production on the cellular level. It has been clearly established in many studies that NAD supplementation increases overall energy and vitality, and may be useful in the treatment of many disorders."
The bottle I bought definitely had NADH on it. Not NAD. Would NAD be inferior, or different in it's actions, since it's been oxidized, coenzyme form?. I had actually used Enada brand ordered online, before I found the Swiss Herbal version, locally (as NADH) in a healthfood store and purchased it for my daughter (last year).
I've emailed the company for more info.
Regards, Jas
poster:jasmineneroli
thread:454017
URL: http://www.dr-bob.org/babble/alter/20050131/msgs/454824.html