Posted by Chairman_MAO on January 11, 2005, at 22:48:21
In reply to Re: What about Galantamine (Reminyl)? - opinions p » Chairman_MAO, posted by barbaracat on January 11, 2005, at 17:24:52
I am posting part of a babblemail I wrote in reply to someone asking me for a justification of why he should take this combination:
picamilon is a moderate gaba uptake inhibitor and mild antidepressant
l-theanine brings about a modest elevation of GABA and dopamine
phenibut is a GABA-B receptor agonist, which is responsible for some of its anxiolytic effect, and its centrally-mediated muscle relaxation. Phenibut also promotes GABA and DA release (250mg three times per day for 10 days brought about a marked improvement in parkinsonian symptoms in one study), and studies in rats show that chronic administration of phenibut increases benzodiazepine receptor expression 25-30%, thereby potentiating activity at GABA-A receptors as well. Phenibut may have additional effects at GABA-A receptors and the BZD receptors, but I don't know if its been well characterized due to the fact that much of the research on it will never be translated into English and was conducted when neuroscience had only the most rudimentary understanding of the BZD receptor. The fact phenibut can cause respiratory depression leads me to believe that it probably does effect the GABA-A receptor in some way.So you see, you have three GABAnergic drugs with different modes of GABAnergic activity, as well as two dopaminergic drugs with two different modes of action (I do not have time to research the mechanism of action of theanine).
I have also taken this combination, and it worked very well. My girlfriend told me it worked very well. I gave it to a friend of mine who was suffering cannabis withdrawal, and it eased his anxiety and a fine tremor. You can try calling the phone # listed on the webpage of smi2le.biz and asking them to ship you the "full strength anxiolytic nootropic formula", which is a combination capsule of all three I designed for them. Their business has been very disorganized as of late, so if you want to be sure you get your stuff fast, I'd order the phenibut from www.1fast400.com and the picamilon and theanine from beyond-a-century.com. You will have to make your own capsules, or used the scoops beyond-a-century gave you and take it with liquid. I forget whether they sell picamilon and theanine caps or not, but I know the phenibut is a bulk powder. Never fear, 250mg is roughly 1/8th of a teaspoon. It's really quite easy with a little practice to weigh 50 capsules worth of powder, blend the powders together, and then fill capsules with a cap-m-quik, and it saves a lot of money. I recommend it, and you can always use it for any bulk supplements you choose to purchase in the future.
Best of health to you.
I said "trust me on this one" because I wanted to contribute to the group and help some people but didn't have time to give a rationale. I really should be getting to bed, but I always feel a drive to help people as well as see if my cocktails work :)
To supercharge the above cocktail, try up to ~450mg of kavalactones per day or gastrodia elata tuber extract standardized for vanillin (if you can find it let me know), which is a potent GABA transaminase inhibitor.
Cheers,
--Blair
poster:Chairman_MAO
thread:435465
URL: http://www.dr-bob.org/babble/alter/20050101/msgs/440913.html