SSRI/dopamine antagonism

Posted by raybakes on December 11, 2004, at 9:13:12

Just came across this study that found that SSRIs upregulate the dopamine transporter (DAT).
"The results demonstrated the inhibition of SERT by SSRI in human in vivo during the chronic treatment and, unexpectedly, an elevation of DAT. This apparent SSRI-induced modulation of the dopamine system may be associated with the side effects of these agents, including sexual dysfunction."

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12589396&dopt=Abstract
Ray

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SSRI/dopamine antagonism raybakes 12/11/04
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