Posted by tealady on November 30, 2004, at 14:05:34
In reply to Re: Larry-question about St. Johns Wort interaction » TenMan, posted by Larry Hoover on November 30, 2004, at 12:07:26
> > Larry, in your opinion do you think that there would be a significant interaction between testosterone therapy (the patch form) and St. Johns Wort due to hepatic enzyme induction?
> >
> > Thanks much.
>
> SJW would reduce the effectiveness of testosterone supps, but I don't think the reduction would be dramatic. Testosterone is mostly bound while circulating in blood, which is to say, it attaches to carrier proteins. Free testosterone only has a half-life of something like twenty minutes, so the big thing is to pump up the bound testosterone levels. Reducing the free half-life from twenty minutes, to say fifteen minutes, is probably not going to be a big deal because the patches supply such a large dose (relative to pre-supplemented testicular output).
>
> Milk thistle inhibits 3A4. Topamax induces it. These things go on all the time, and no one is much the wiser.
>
> Lar
Hi Lar ..on milk thistle inhibiting 3A4.
I guess that's a liver enzyme?
What does it do? (if you know offhand) and what has this got to do with IL-6?
I've just started taking milk thistle(Solgar) this week to hopefully support my liver.Thanks, Jan
poster:tealady
thread:422170
URL: http://www.dr-bob.org/babble/alter/20041123/msgs/422428.html