Posted by chemist on June 22, 2004, at 18:46:08
In reply to Re: on the contrary, posted by linkadge on June 22, 2004, at 17:57:00
> MAOB properties
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> http://biopsychiatry.com/kavakava.htm
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> Argument about the valitity of liver toxicity
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> http://biopsychiatry.com/kavasaferisk.htm
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> Noting that many of the claimed cases involved the concurrent usage of conventional anxiolitics.
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> Reference for kava/gaba interaction
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> Jussofie A, Schmiz A, Hiemke C. Kavapyrone enriched extract from Piper methysticum as modulator of the GABA binding site in different regions of rat brain. Psychopharmacology. 1994;116:469–474
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> Kava's Role in Cognition / Nootropic properties
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> Enhanced cognitive performance and cheerful mood by standardized extracts of Piper methysticum (Kava-kava).
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> The acute effects of the herbal anxiolytic Kava-kava (Piper methysticum G. Forster) on emotional reactivity and cognitive performance were investigated in a double-blind randomized placebo-controlled trial involving healthy volunteers. Subjects' reports of mood change were assessed with the state-trait-cheerfulness-inventory, which measures the three concepts of cheerfulness, seriousness and bad mood as both traits and states. Cognitive performance was examined with the Sperling partial report and the Sternberg item recognition task, which were used as an index for visual attention and short-term memory processing. The intake of a single dose of Kava extract (300 mg; p.o.) led to an increase in state cheerfulness, while the phytopharmacon did not influence state seriousness and bad mood. The mood-elevating effects of Kava were most prominent in trait cheerful subjects, indicating that trait cheerfulness moderated the drug-induced increase in cheerful mood. Furthermore, Kava improved the accuracy and the speed of performing the partial report and the item recognition task, indicative of a beneficial
> effect of the phytopharmacon on visual attention and short-term memory retrieval, respectively. Thus, unlike conventional benzodiazepine-type anxiolytics, which tend to impair cognitive performance and to increase the occurrence of negative affective states, Kava is a potent anxiolytic agent, which, additionally, can facilitate cognitive functioning and can increase positive affectivity related to exhilaration.
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thanks, i should have been more specific in re: peer-review, refereed pubs (in reference to the websites to which your point). i will mention i am highly skeptical of xxx, because from their home page, i was able to get a list of offshore/Mexican pharmacies (click on xxx). plus, while on the same page, you can get to xxx, all from xxx. my favorite quote - right on the home page is xxx. this source is, in my opinion, lacking. in so many ways.the abstract about the MAOB connection is the one i referenced with sub-micromolar K_{i}. just wondering why there are no drugs being marketed based on kave pyrones for MAOIs.....
the gaba/kava pub. mentions modulation of the GABA_{A} muscimol binding sites, not GABA sites, and not GABA. hence, no connection in this pub.
the abstract about cheerfulness assiciated with kava is one i came across on pubmed and dismissed because the authors conclude that because a person who is exhilirated due to the psychotropic effects of kava can recall images and exhibits less short-term memory loss, hardly indicators of nootropic efficacy. we are talking about long-term neurodegerenative effects. kava kava in not on the radar of those of us who work on therapies for Alzheimer's, i can assure you....all the best, chemist
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poster:chemist
thread:358292
URL: http://www.dr-bob.org/babble/alter/20040613/msgs/359206.html