Posted by PeterMartin on August 4, 2023, at 6:07:59
In reply to Re: hormones and depression, posted by SLS on March 25, 2006, at 19:35:50
> > also there's cortisol--there's that new cortisol-lowering drug (I think its just RU-486 in different packagint) that apparently does wonders for psychotic depression. I imagine it will probably be used for other disorders, too.
>
> RU-486 is now called mifepristone (Mifeprex).
>
> The NIMH has an ongoing study of mifepristone to treat bipolar disorder. The drug is a cortisol receptor blocker. I tried it for bipolar depression. I thought there might have been a trend towards imrovement after the first 3 days, but it did not persist.
>
> The current protocol calls for the patient to take 600mg of mifepristone a day for 8 consecutive days. The drug is then discontinued. Ideally, one begins to respond by the end of the treatment period. The antidepressant effect is supposed to persist beyond active treatment; the idea being that the the drug has forced the body to reset the HPA axis and normalize cortisol dynamics.
>
>
> - Scott
Did the mentioned study post results? Obv being from 2006 the study must have concluded. Read a paper that mentioned Mifepristone which had me googling
poster:PeterMartin
thread:624196
URL: http://www.dr-bob.org/babble/20230117/msgs/1122150.html