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Re: Guanfacine + NAC for PTSD, TBI, ADHD, long Covid

Posted by SLS on January 6, 2023, at 20:14:30

In reply to Re: Guanfacine + NAC for PTSD, TBI, ADHD, long Covid SLS, posted by Jay2112 on January 6, 2023, at 19:58:49

> > > Twelve patients with "brain fog" including difficulties in executive functions were treated with guanfacine (1mg, PO [by mouth] bedtime for the first month, increased to 2mg after 1 month, if well-tolerated) and 600 mg NAC daily.
> > >
> > > Guanfacine+NAC improved cognitive abilities in eight of the twelve patients; four patients discontinued therapy, two for unspecified reasons and two due to hypotension and/or dizziness, common side effects of guanfacine.
> > >
> > > Those who stayed on guanfacine+NAC reported improved working memory, concentration, and executive functions, including a resumption of normal workloads. One patient briefly stopped taking guanfacine due to a hypotensive episode and reported a return of cognitive deficits that abated with resumed guanfacine treatment.
> > >
> > >
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> > >
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> > Does guanfacine produce depression as a side effect as often as clonidine does?
> >
> >
> > - Scott
> I don't think guanfacine is as strong a sedative as clonidine.

Which is better for ADHD?

> I honestly did not find clonidine depressing, but just that it slows you down. I think because of the norepinephrine suppression, it also makes you achy and tired. But that is dose dependent.

Clonidine is notorious for producing a very real depressive state. A doctor gave my maternal grandmother clonidine for hypertension. She had no history of having a depressive mood disorder. Within a week of beginning clonidine, she became visibly depressed. She laid on the couch and watched Judge Judy all day long. She didn't pick up a book. Reading was her greatest joy. Fortunately, I was well aware of depression being a sequala of taking clonidine. Once she discontinued clonidine, her depression lifted within a few days.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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