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Re: Going with Venlafainxe + Bupropion » undopaminergic

Posted by jay2112 on November 19, 2022, at 14:38:39

In reply to Re: Going with Venlafainxe + Bupropion, posted by undopaminergic on November 18, 2022, at 9:47:48

> >
> > -----------------------------------------------------
> >
> > 1. Low dosages of lithium: Improves depression only.
> >
> > 2. Low levels of glutamate are associated with depression.
> >
> > -----------------------------------------------------
> >
> > 1. High dosages of lithium: Used traditionally for bi1. polar disorder. High dosages are necessary as an acute treatment for an ongoing episode of a mania or for its prophylaxis.
> >
> > 2. High levels of glutamate are associated with mania.
> >
> > ------------------------------------------------------
> >
>
> The evidence seems to be conflicting. Ketamine, a NMDA-glutamatergic antagonist, improves depression. Memantine, another NMDA-glutamatergic antagonist, can induce mania.
>
> There must be an explanation of course. Perhaps antagonising the NMDA-subtype receptors triggers an increase in glutamatergic tone at other receptor subtypes.
>
> -undopaminergic
>

Like SSRI's, glutamatergic drugs often start out as agonists, then down-regulate and antagonize. Low dose lithium = pro-glutamatergic...high dose down-regulates. Perhaps a higher dose of Memantine would down-regulate, and depress?

I dunno...just a guess.

Jay


Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-


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poster:jay2112 thread:1121058
URL: http://www.dr-bob.org/babble/20220917/msgs/1121091.html