Posted by SLS on August 22, 2022, at 19:16:33
In reply to Re: Venlafaxine is not an SSRI » Christ_empowered, posted by beckett2 on August 21, 2022, at 22:01:01
What I was trying to say is that the antidepressant response you experience is, on an extremely simplistic level, counterintuitive when considering the recent work with lithium and glutamate activity. That work reports a bimodal action of lithium on glutamate activity based upon dosage. At low dosages, lithium promotes an increase in glutamate activity. At higher dosage, lithium reduces glutamate activity. Glutamate is the most ubiquitous excitatory neurotransmitter. At lower dosages, lithium can have an antidepressant effect, but not an antimanic effect.
So, the question is, why do the actions of lamotrigine and ketamine to reduce glutamate activity produce an antidepressant effect when the low dosages of lithium known to exert an antidepressant effect increase glutamate activity.
Man's models of how the brain works are full of contradictions. Of course, the workings of the brain has no real contradictions. It knows very well how it works.
I think your combining lamotrigine and ketamine is a great idea.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.The only thing necessary for the triumph of evil is that good men do nothing.
poster:SLS
thread:1120378
URL: http://www.dr-bob.org/babble/20220530/msgs/1120439.html