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Ritalin + an MAOi = Greater baseline D/NE?

Posted by PeterMartin on October 5, 2021, at 0:35:16

I take Marplan (MAOi) and have recently added Ritalin again. I don't have any interactions between the 2, so I take a relatively "normal" dose of Ritalin IR at 40mg per day.

I know Ritalin (methylphenidate) works by increasing Norepinephrine and Dopamine in the brain, but it also has a short half-life of ~3hrs. Most people take it a few times a day, or an extended release variety to keep the effects.

My question is, being on an MAOi will taking Ritalin raise my baseline levels of Norepinephrine & dopamine over time, where it wouldn't in people who don't have their MAO inhibited?

I guess I'm wondering if it'd have more of an effect on me over time compared to other people.

I did take it along w/ Nardil & Marplan a while back for a couple of years, but I never really knew if it helped my mood aside from the immediate effects.

Thanks for any insight/discussion.




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