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Re: Why do meds constantly stop working for me? SLS

Posted by undopaminergic on September 30, 2021, at 13:28:02

In reply to Re: Why do meds constantly stop working for me? undopaminergic, posted by SLS on September 30, 2021, at 11:43:01

> "amphetaminergic"
> Perfect!
> - Scott

Haha, yes, but more soberly, it should perhaps be "trace amine-like". Amphetamine is a synthetic analogue of trace amines like tyramine and (especially) phenylethylamine (PEA).

I used-abused PEA chronically myself for its amphetaminergic actions. This was the most harmful psychopharmacological act I ever engaged in, although reboxetine (Edronax) markedly worsened depersonalisation-derealisation. Without either of them, I would (probably) be much better off today.

Before PEA, I deemed methylphenidate (Concerta) not to be worth the money and voluntarily quit it. After PEA, methylphenidate (or its workalikes) was essential just to ward off apathy and suicidal ideation. There are marked similarities between myself and those who are recovering from chronical methamphetamine abuse. Why did I quit? It's pathetic. I ran out of my local supply, and couldn't muster the motivation for a short trip into town to get a refill. I felt like a dirty damp and worn-out old rag, out of which all dopamine had been wrung. That is an analogy that is close to the literal state I was in. I'm still recovering.

Particularly esoteric knowledge: as of today, I'm down to only 37 mg lurasidone (Latuda). Next thursday we'll be going down to 0 mg. Question: should I first (a) substitute clomipramine for trimipramine, or (b) start asenapine?





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