Posted by Hugh on August 10, 2021, at 10:12:19
In reply to A surprising neurological treatment, posted by Hugh on August 8, 2021, at 11:21:21
The low dose of radiation (LDR) has received growing attention for its beneficial neuroprotective effect. This study was designed to investigate the enhancing effect of LDR on the antidepressant potential of resveratrol against diazepam-induced depression in mice. Female mice divided into five groups; control, diazepam (2 mg/kg), LDR (0.5Gy) + diazepam, resveratrol (20 mg/kg) + diazepam, LDR + resveratrol+diazepam. Mice received diazepam showed depressive symptoms as evidenced by decreased locomotor activity in the open field and increased immobility time in the forced swimming and tail suspension tests integrated with a marked decline in biogenic amines (serotonin, norepinephrine, and dopamine) in brain tissues. These effects were ameliorated by LDR or resveratrol administration demonstrating an antidepressant activity. Interestingly, LDR triggered the antidepressant effect of resveratrol as it restored the changes in behavioral tests, neurotransmitters, and neuro-histoarchitecture. In conclusion, these findings suggested that LDR could be considered as a novel adjuvant that augmented the resveratrol antidepressant effect and might serve as a potential therapeutic approach for depression.
Environ Toxicol 2020 Oct;35(10):1137-1145.
doi: 10.1002/tox.22949. Epub 2020 May 28.https://pubmed.ncbi.nlm.nih.gov/32463565/
Another low dose radiation study:
poster:Hugh
thread:1116304
URL: http://www.dr-bob.org/babble/20210723/msgs/1116339.html