Psycho-Babble Medication | about biological treatments | Framed
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Re: What are the overall best antipsychotics...?

Posted by undopaminergic on May 21, 2020, at 12:15:00

In reply to Re: What are the overall best antipsychotics...?, posted by Lamdage22 on May 21, 2020, at 11:09:12

> If you ask me, D2 antagonistic Antipsychotics do nothing for depression unless they somehow raise Dopamine at a low dose. Sulpiride, Amisulpiride. Maybe others.

Sulpiride and amisulpride preferentially block presynaptic dopamine autoreceptors, increasing dopamine release.

Flupenthixol is antidepressive, but I don't know what its mechanism of action might be.

> The abilifyish meds are different, because they sort of modulate Dopamine instead of killing it.

Yes, they are partial agonists. They antagonise when endogenous dopamine is high, and stimulate when dopamine is low.





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