Posted by undopaminergic on March 23, 2020, at 12:18:45
In reply to Re: AP's and relief, posted by Lamdage22 on March 23, 2020, at 7:16:03
> Sedation and Weight Gain (Although i can now fight it). And weird dreams. Some people go from skinny to XXL in a matter of weeks. Not healthy. I do take Metformin for this, but it doesn't work for everyone.
>Very common with most atypicals. But not all of them are as strong antihistamines as Seroquel and Zyprexa. Indeed some of them have negligible affinity for the histamine H1-receptor.
Have you considered amisulpride (or sulpiride; maybe tiapride), lurasidone, blonanserin, sertindole, or cariprazine?
The "old-style" APs also cause less weight gain, although they are more likely to provoke the antipyramidal side effects. Some examples of typicals with low histamine H1-affinity are haloperidol, thiothixene, perphenazine, trifluoperazine, and fluphenazine. At least some of these, such as haloperidol, are very effective APs.
My psychiatrist thinks Seroquel is a poor antipsychotic. A nurse I've spoken with is of a similar opinion. It is also *very* antihistaminic -- only clozapine has a higher histamine H1 affinity relative to dopamine D2.
What all APs have in common is the D2-antagonism. Clozapine is the mildest at the D2, yet it is regarded as the most effective. It is the preferred AP for psychosis in Parkinson's disease.
-undopaminergic
poster:undopaminergic
thread:1109162
URL: http://www.dr-bob.org/babble/20200303/msgs/1109179.html