Caplyta

Posted by phidippus on January 18, 2020, at 20:30:30

Lumateperone affects multiple systems (serotonergic, dopaminergic and glutamatergic) in the central nervous system. It acts as a antagonist of 5HT2A 0.54nM receptor and modulates D1 4.1nM and D2 3.2nM dopamine receptors where it is a partial agonist at presynaptic and antagonist at postsynaptic receptors. Serotonin transporters at 3.3nM. Through the mTOR pathway, lumateperone augments both NMDA and AMPA activity. Because of its complex pharmacology, it is not clear which of these activities are primarily responsible for its antidepressive and antipsychotic activities.
Very interesting.
Phidippus
Dx
Bipolar I
OCD
Rx
8 mg Gabitril
750 mg Lithium
15 mg Trintellix
20 mg Zyprexa

Thread

Caplyta phidippus 1/18/20
Re: Caplyta Lamdage22 1/19/20
Re: Caplyta Lamdage22 1/19/20
Re: Caplyta undopaminergic 1/19/20
MAGIC MUSROOM FDA TEST FOR TRD depression greg rizzo 1/19/20
Re: MAGIC MUSROOM FDA TEST FOR TRD depression undopaminergic 1/19/20
Re: MAGIC MUSROOM FDA TEST FOR TRD depression greg rizzo 1/19/20
Re: MAGIC MUSROOM FDA TEST FOR TRD depression » greg rizzo undopaminergic 1/19/20
Re: Caplyta Lamdage22 1/19/20
Re: Caplyta » Lamdage22 phidippus 1/19/20
Re: MAGIC MUSROOM FDA TEST FOR TRD depression » greg rizzo phidippus 1/19/20
This thread is for Caplyta, not MAGIC MUSHROOMS... » greg rizzo phidippus 1/19/20
Re: Caplyta Lamdage22 1/19/20
Re: Caplyta Lamdage22 1/19/20
Re: Caplyta undopaminergic 1/20/20
Re: Caplyta Lamdage22 1/20/20
Re: This thread is for Caplyta, not MAGIC MUSHROOMS... greg rizzo 1/20/20
Re: MAGIC MUSROOM FDA TEST FOR TRD depression greg rizzo 1/20/20
Re: This thread is for Caplyta, not MAGIC MUSHROOMS... Lamdage22 1/20/20
Re: Caplyta undopaminergic 1/20/20
Re: Caplyta Lamdage22 1/20/20
Re: Caplyta undopaminergic 1/20/20
Re: Caplyta Lamdage22 1/20/20
Re: Caplyta Lamdage22 1/21/20

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