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Re: What do TRD patients take without an MAIO linkadge

Posted by undopaminergic on December 4, 2019, at 9:07:46

In reply to Re: What do TRD patients take without an MAIO undopaminergic, posted by linkadge on December 2, 2019, at 9:11:20

> Nice chat,
>

Glad you like it, even though I'm not at my best.

> Amphetamines are not always neurotoxic.
>

No, it's dose related. There is a point at which elevated extracellular dopamine begins to produce oxidative stress. Eg. cocaine and even more potent dopamine reuptake inhibitors do not achieve toxic DA elevations. Amphetamines do have that power (again, provided the dose is high enough).

Many people with ADD/ADHD who take it as prescribed continue to enjoy therapeutic benefits in the long term.

> In lower dose paradigms (i.e. stroke rehabilitation) they can actually be neurotrophic. I remember reading a study that low dose meth actually enhanced synaptic plasticity and recovery after TBI.
>

Interesting. I didn't know.

> I've never taken selegiline but I often do well by adding the herb FO-TI (purportedly fairly selective towards MAO-B) and it helps quite a bit with energy and focus.
>

That's great that you have found something that helps.

> In my own experience with monoamine reuptake inhibitors and MAOIs, MAOIs produce a much different feel to them. For MAO-A, there are other trace amines (such as tryptamine) whose elevation may enhance the clinical effect as dose psychedelics may have antidepressant effects for some individuals.
>

I'd really like to try tranylcypromine, or failing that, isocarboxazide or EMSAM, but they aren't available where I live (Nordic countries).

You can safely add NRIs and DRIs to a MAOI. NRIs even counteract tyramine, because they reduce the uptake of tyramine (via the reuptake transporter) into sympathetic nerve terminals.

-undopaminergic


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