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Re: high dose of venlafaxine (effexor)

Posted by linkadge on August 3, 2019, at 10:16:16

In reply to Re: high dose of venlafaxine (effexor), posted by longrunner on August 3, 2019, at 8:34:50

In theory, reboxetine should be as effective as any other norepinephrine reuptake inhibitor. However, a drug like atomoxetine for example (a potent NRI) has little / no antidepressant effects. Reboxetine could be a decent adjunct, but yet not super effective on its own right. I'm guessing that if you put reboxetine and desipramine head to head, desipramine would prove a more effective antidepressant.

Some people do need higher doses of meds, and that's not an issue. However, 750mg of Effexor is a really high dose and it may be indicative of other issues. For example, have you been tested for ADHD? It's possible that the (short term) stimulant like qualities of Effexor could be treating ADHD for a time. Fetzima (levomilnacipran) may also be more effective than endronax.

Have you considered adding a mood stabilizer? Sometimes these meds can help antidepressants work better (via balancing glutamate / gaba systems).





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