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AD effectiveness: Am i under the right impression?

Posted by mtom on July 28, 2019, at 19:13:38

In reply to Re: Am i under the right impression?, posted by Lamdage22 on July 28, 2019, at 11:28:00

Coincidental you posted this because I had been in the process of writing a rather long post about AD effectiveness and the whole monoamine theory - which is increasingly being questioned.

Then I accidentally closed the window before I posted it!!

I had included the following excerpt from a recently published paper: "Both the limited effectivity of existing AD and the scarcity of novel options may stem from a once revolutionary, yetin retrospectexcessive and misguided focus on the monoamine hypothesis for the pathophysiology of depression, which centers on defective neurotransmission of serotonin (5-hydroxytriptamine, 5HT), noradrenaline (NA), and dopamine (DA) in the brain. Indeed, the serendipitous discovery of tricyclic AD drove the reverse engineering of this hypothesis, which in turn has guided much of the development of all AD throughout history.
Nevertheless, the monoamine hypothesis has been heavily contested regarding its validity and the relative importance of its components..."

In any event, you're right that most of the people who visit sites like this are those who are not getting the results they want from their medications. However - I think that is a fairly high proportion as many articles and papers report effects of AD's not really as much higher than placebo than one would hope. And also many articles state they don't work on at least 30% of those who try them (some quote higher numbers).

The paper I quoted from above is titled:
Depression as a Neuroendocrine Disorder: Emerging Neuropsychopharmacological Approaches beyond Monoamines

There is also at least 1 study currently underway to determine the affect of treating depression with a Biologic Medication usually used to treat Rheumatoid Arthritis. Much has been recently written about the hypothesis of Depression being, at least in some cases, an autoimmune or inflammatory disorder.




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