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Re: Why is Prozac not prescribed much any more? Hordak

Posted by mtom on July 16, 2019, at 19:12:56

In reply to Re: Why is Prozac not prescribed much any more?, posted by Hordak on July 16, 2019, at 17:28:38

> Because many interactions via CYP450.

Thanks Hordak, I do understand about interactions. However this applies to all the AD's as they are all metabolized by enzymes of the P450 system, many by CYP2D6, some also by other CYP enzymes. As are many other medications (I had Genetic Testing for medications done last year and have researched this topic a lot as I believe it is applicable to adverse reactions and efficacy).

Since writing the first post, I am reading that Prozac is, in fact, still widely prescribed (including 2 previous posters to this thread). This surprised me as I don't personally know anyone who is taking it - although this is a fairly limited number. I suspect others I know take an AD, but just don't talk about it.

People who have mentioned their current AD's to me are taking Celexa (citalopram), Cipralex/Lexapro (escitalopram), Bupropion (Wellbutrin), Venlafaxine (Effexor), Sertraline (Zoloft), and someone who recently started Trintellix (Vortioxetine) - the latter having switched from something else due to adverse effects (don't know what he was taking previously).




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