Posted by Ruuudy on July 5, 2019, at 17:49:02
In reply to Re: Spravato (esketamine) » Ruuudy, posted by pedr on July 5, 2019, at 10:53:37
> Thanks for the update Rudy. How is it faring when you're not under its immediate effects e.g. in between doses? Has it lifted your mood overall?
When I first walk out of the office following the 2 hour visit, I feel like I just got out of surgery. The next morning, I'm not jumping with bundles of joy & energy, but I can say I probably have a slight lift in mood.
I still have not taken my stimulant (dextroamphetamine), nor my benzo (clonazapam) since beggining Spravato treatment.I had my 8th treatment yesterday and will go a full week between treatments this time.
I am also scheduled to bump up to 84mg next Friday to start the "once a week" treatments.>
> BTW I saw this https://www.psychologytoday.com/us/blog/evolutionary-psychiatry/201907/esketamine-depression-new-fda-approval-new-controversy which was a good read, esp. about discontinuation :
>
> "JAMA Psychiatry also released a paper earlier this month that looked at longer-term treatment with esketamine. This study took 297 patients whose depression responded to esketamine + antidepressant and enrolled them in a randomized discontinuation phase after 16 weeks of treatment. Half continued with esketamine + antidepressant, the other half a placebo nasal spray and antidepressant, and were followed for about two years. Here the differences got quite significant: Continuing esketamine decreased risk of relapse of depression by 50-70% compared to placebo. Half of the relapses occurred in the first four weeks after stopping esketamine."
>
> PeteThanks for the link. Gonna read right now.
As long as I believe there's a cumlative effect with a possibility of additional improvement, I don't mind going in for treatments.I will let you'all know how the longer time between treatments goes. Thanks!
Rudy
poster:Ruuudy
thread:1104865
URL: http://www.dr-bob.org/babble/20190513/msgs/1105168.html