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Re: Why do people not like Amitriptyline + Mirtazapine

Posted by SLS on July 2, 2019, at 12:03:10

In reply to Re: Why do people not like Amitriptyline + Mirtazapine, posted by Hordak on July 1, 2019, at 15:04:13

> There is no logic in combining Amitriptyline and Mirtazapine: Both are strong antihistamines and strong 5HT2 antagonists... so why take them both?

Perhaps there is some logic. Amitriptyline is a reuptake inhibitor, primarily of norepinephrine. It also inhibits the reuputake of serotonin to some extent. Mirtazapine does neither of these things. I guess it is possible that that the NE reuptake inhibition of amitriptyline will work synergistically with the NE alpha2 antagonism of mirtazapine. I don't think I have seen these two drugs combined, though. I would think that using nortriptyline would be a better choice to combine with mirtazapine because it is not antihistaminic. I haven't seen this combination used, either.


- Scott
>


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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